Publications of Manfred T. Reetz

Hollmann, F.; Sanchis Martinez, J.; Reetz, M. T.: Learning from Protein Engineering by Deconvolution of Multi-Mutational Variants. Angewandte Chemie International Edition, e202404880 (2024)

Mei, Z.-L.; Li, C.-C.; Han, X.; Tian, Y.-C.; Li, S.-H.; Liu, W.; Qu, G.; Reetz, M. T.; Sun, Z.; Ma, J.-A. et al.; Zhang, F.-G.: Enzymatic Stereodivergent Access to Fluorinated β-Lactam Pharmacophores via Triple-Parameter Engineered Ketoreductases. ACS Catalysis 14 (8), pp. 6358 - 6368 (2024)

Reetz, M. T.; Qu, G.; Sun, Z.: Engineered enzymes for the synthesis of pharmaceuticals and other high-value products. Nature Synthesis 3, pp. 19 - 32 (2024)

Reetz, M. T.; Hollmann, F.: Breakthrough in the challenging P450-catalyzed chemoenzymatic synthesis of C14-functionalized steroids. Science China Chemistry 66 (9), pp. 2435 - 2436 (2023)

Reetz, M. T.: Dyotropic Rearrangements in Organic Solvents, in the Gas Phase, and in Enzyme Catalysis. Israel Journal of Chemistry 63 (7-8), e202200122 (2023)

Li, A.; Wang, Q.; Song, X.; Zhang, X.; Huang, J.-W.; Chen, C.-C.; Guo, R.-T.; Wang, B.; Reetz, M. T.: Engineering of a P450-based Kemp eliminase with a new mechanism. Chinese Journal of Catalysis 47, pp. 191 - 199 (2023)

Li, J.-K.; Qu, G.; Li, X.; Tian, Y.; Cui, C.; Zhang, F.-G.; Zhang, W.; Ma, J.-A.; Reetz, M. T.; Sun, Z.: Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles. Nature Communications 13, 7813 (2022)

Reetz, M. T.: Witnessing the Birth of Directed Evolution of Stereoselective Enzymes as Catalysts in Organic Chemistry. Advanced Synthesis & Catalysis 364 (19), pp. 3326 - 3335 (2022)

Reetz, M. T.: Making Enzymes Suitable for Organic Chemistry by Rational Protein Design. Chembiochem 23 (14), e202200049 (2022)

Dong, Y.; Li, T.; Zhang, S.; Sanchis, J.; Yin, H.; Ren, J.; Sheng, X.; Li, G.; Reetz, M. T.: Biocatalytic Baeyer–Villiger Reactions: Uncovering the Source of Regioselectivity at Each Evolutionary Stage of a Mutant with Scrutiny of Fleeting Chiral Intermediates. ACS Catalysis 12 (6), pp. 3669 - 3680 (2022)

Reetz, M. T.; König, G.: n-Butanol: An Ecologically and Economically Viable Extraction Solvent for Isolating Polar Products from Aqueous Solutions. European Journal of Organic Chemistry 2021 (46), pp. 6224 - 6228 (2021)

Reetz, M. T.: Effective Mentoring and the Problem of Assessing Quality in Science. Helvetica Chimica Acta 104 (10), e2100124 (2021)

Reetz, M. T.; Garcia-Borràs, M.: The Unexplored Importance of Fleeting Chiral Intermediates in Enzyme-Catalyzed Reactions. Journal of the American Chemical Society 143 (37), pp. 14939 - 14950 (2021)

Acevedo-Rocha, C. G.; Li, A.; D'Amore, L.; Hoebenreich, S.; Sanchis, J.; Lubrano, P.; Ferla, M. P.; Garcia-Borràs, M.; Osuna, S.; Reetz, M. T.: Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics. Nature Communications 12 (1), 1621 (2021)

Li, G.; Qin, Y.; Fontaine, N. T.; Ng Fuk Chong, M.; Maria-Solano, M. A.; Feixas, F.; Cadet, X. F.; Pandjaitan, R.; Garcia‐Borràs, M.; Cadet, F. et al.; Reetz, M. T.: Machine Learning Enables Selection of Epistatic Enzyme Mutants for Stability Against Unfolding and Detrimental Aggregation. Chembiochem 22 (5), pp. 904 - 914 (2021)

Reetz, M. T.: A breakthrough in protein engineering of a glycosyltransferase. Green Synthesis and Catalysis 2 (1), pp. 4 - 5 (2021)

Lehmann, U.; Goddard, R.; Tonner, R.; Reetz, M. T.: Towards self-doping multimetal porphyrin systems. Journal of Porphyrins and Phthalocyanines 25 (2), pp. 162 - 167 (2021)

Reetz, M. T.: Effective mentoring ensures the progress of science. Journal of Biology 37 (6) (2020)

Qu, G.; Li, A.; Acevedo-Rocha, C. G.; Sun, Z.; Reetz, M. T.: The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes. Angewandte Chemie, International Edition 59 (32), pp. 13204 - 13231 (2020)

Li, A.; Acevedo-Rocha, C. G.; D'Amore, L.; Chen, J.; Peng, Y.; Garcia‐Borràs, M.; Gao, C.; Zhu, J.; Rickerby, H.; Osuna, S. et al.; Zhou, J.; Reetz, M. T.: Regio‐ and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants. Angewandte Chemie International Edition 59 (30), pp. 12499 - 12505 (2020)