Publications of Richard Lonsdale

Acevedo-Rocha, C. G.; Gamble, C. G.; Lonsdale, R.; Li, A.; Nett, N.; Hoebenreich, S.; Lingnau, J. B.; Wirtz, C.; Fares, C.; Hinrichs, H.; Deege, A.; Mulholland, A. J.; Nov, Y.; Leys, D.; McLean, K. J.; Munro, A. W.; Reetz, M. T. P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping. ACS Catalysis 2018, 8, 3395–3410.

Qu, G.; Lonsdale, R.; Yao, P.; Li, G.; Liu, B.; Reetz, M. T.; Sun, Z. Methodology Development in Directed Evolution: Exploring Options when Applying Triple-Code Saturation Mutagenesis. Chembiochem 2018, 19, 239–246.

Sun, Z.; Wu, L.; Bocola, M.; Chan, H. C. S.; Lonsdale, R.; Kong, X.-D.; Yuan, S.; Zhou, J.; Reetz, M. T. Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations. Journal of the American Chemical Society 2018, 140, 310–318.

Li, G.; Yao, P.; Gong, R.; Li, J.; Liu, P.; Lonsdale, R.; Wu, Q.; Lin, J.; Zhu, D.; Reetz, M. T. Correction: Simultaneous Engineering of an Enzyme’s Entrance Tunnel and Active Site: the Case of Monoamine Oxidase MAO-N. Chemical Science 2017, 8, 4666–4666.

Li, G.; Yao, P.; Gong, R.; Li, J.; Liu, P.; Lonsdale, R.; Wu, Q.; Lin, J.; Zhu, D.; Reetz, M. T. Simultaneous Engineering of an Enzyme's Entrance Tunnel and Active Site: the Case of Monoamine Oxidase MAO-N. Chemical Science 2017, 8, 4093–4099.

Muche, S.; Levacheva, I.; Samsonova, O.; Biernasiuk, A.; Malm, A.; Lonsdale, R.; Popiołek, Ł.; Bakowsky, U.; Hołynska, M. Synthesis, Structure and Stability of a Chiral Imine-Based Schiff-Based Ligand Derived from L-Glutamic Acid and its [Cu₄] Complex. Journal of Molecular Structure 2017, 1127, 231–236.

Sun, Z.; Lonsdale, R.; Li, G.; Reetz, M. T. Comparing Different Strategies in Directed Evolution of Enzyme Stereoselectivity: Single- Versus Double-Code Saturation Mutagenesis. Chembiochem 2016, 17, 1865–1872.

Li, A.; Ilie, A.; Sun, Z.; Lonsdale, R.; Xu, J.-H.; Reetz, M. T. Whole-Cell-Catalyzed Multiple Regio- and Stereoselective Functionalizations in Cascade Reactions Enabled by Directed Evolution. Angewandte Chemie International Edition 2016, 55, 12026–12029.

Sun, Z.; Torres Salas, P.; Siirola, E.; Lonsdale, R.; Reetz, M. T. Exploring Productive Sequence Space in Directed Evolution Using Binary Patterning Versus Conventional Mutagenesis Strategies. Bioresources and Bioprocessing 2016, 3, 1–8.

Wang, J.; Lonsdale, R.; Reetz, M. T. Exploring Substrate Scope and Stereoselectivity of P450 Peroxygenase OleTJE in Olefin-Forming Oxidative Decarboxylation. Chemical Communications 2016, 52, 8131–8133.

Sun, Z.; Lonsdale, R.; Ilie, A.; Li, G.; Zhou, J.; Reetz, M. T. Catalytic Asymmetric Reduction of Difficult-to-Reduce Ketones: Triple Code Saturation Mutagenesis of an Alcohol Dehydrogenase. ACS Catalysis 2016, 6, 1598–1605.

Sun, Z.; Lonsdale, R.; Li, G.; Li, A.; Wang, J.; Reetz, M. T. Structure-Guided Triple-Code Saturation Mutagenesis: Efficient Tuning of the Stereoselectivity of an Epoxide Hydrolase. ACS Catalysis 2016, 6, 1590–1597.

Lonsdale, R.; Reetz, M. T. Reduction of α,β-Unsaturated Ketones by Old Yellow Enzymes: Mechanistic Insights from Quantum Mechanics/Molecular Mechanics Calculations. Journal of the American Chemical Society 2015, 137, 14733–14742.

Lonsdale, R.; Reetz, M. T. Reduction of α,β-Unsaturated Ketones by Old Yellow Enzymes: Mechanistic Insights from Quantum Mechanics/Molecular Mechanics Calculations. Journal of the American Chemical Society 2015, 137, 14733–14742.

Ritter, C.; Nett, N.; Acevedo-Rocha, C. G.; Lonsdale, R.; Kraling, K.; Dempwolff, F.; Hoebenreich, S.; Graumann, P. L.; Reetz, M. T.; Meggers, E. Bioorthogonal Enzymatic Activation of Caged Compounds. Angewandte Chemie International Edition 2015, 54, 13440–13443.

Sun, Z.; Lonsdale, R.; Kong, X.-D.; Xu, J.-H.; Zhou, J.; Reetz, M. T. Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution. Angewandte Chemie International Edition 2015, 54, 12410–12415.

Sun, Z.; Lonsdale, R.; Kong, X.-D.; Xu, J.-H.; Zhou, J.; Reetz, M. T. Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution. Angewandte Chemie International Edition 2015, 54, 12410–12415.

Ilie, A.; Lonsdale, R.; Agudo Torres, R.; Reetz, M. T. A Diastereoselective P450-Catalyzed Epoxidation Reaction: Anti Versus Syn Reactivity. Tetrahedron Letters 2015, 56, 3435–3437.

Agudo Torres, R.; Roiban, G.-D.; Lonsdale, R.; Ilie, A.; Reetz, M. T. Biocatalytic Route to Chiral Acyloins: P450-Catalyzed Regio- and Enantioselective α-Hydroxylation of Ketones. The Journal of Organic Chemistry 2015, 80, 950–956.

Zhang, Z.-G.; Londsdale, R.; Sanchis-Martinez, J.; Reetz, M. T. Extreme Synergistic Mutational Effects in the Directed Evolution of a Baeyer–Villiger Monooxygenase as Catalyst for Asymmetric Sulfoxidation. Journal of the American Chemical Society 2014, 136, 17262–17272.